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The Science, Studies and References behind Red Light Therapy And Infrared Light Medicine

The Science, Studies and References behind Red Light Therapy And Infrared Light Medicine

Red Light Therapy is one of the fastest growing trends in the Wellness Industry

Below Are Links to Our Favorite Studies Demonstrating The Effects of Red Light and Infrared Therapy - over 100 cases providing depth and understanding as to why Light Medicine is one of the greatest discoveries in natural healing, wellness, and rejuvenation for both the mind and body.

1. History - Frieman, father of LLLT


2. History, Mechanism, Dose, Mitochondrial, Anti-inflammatory


3. History, Mechanism, Dose, Mitochondrial, Anti-inflammatory


4. Visible Light therapy vs. Near Infrared Light therapy


5. History, Mechanism, Dose, Mitochondrial, Antinflammatory


Sunlight Incidence, Vitamin D Deficiency, and Alzheimer's Disease


6. Artificial Light and Cancer - Mal Illumination


7. Artificial Light and Obesity



8. Light at night clock and metabolism


9. History, Mechanism, Dose, Mitochondrial, Antinflammatory


10. Diabetic Neuropathy


Hair Loss

11. https://www.aad.org/media/stats/conditions/skin-conditions-by-the-numbers

12. https://www.ncbi.nlm.nih.gov/pubmed/23970445

Wound Healing, dairy cattle, cat tongue

13. https://www.ncbi.nlm.nih.gov/pubmed/9068161

14. https://pdfs.semanticscholar.org/7762/57f1debd12c652310bd11d8d53cfc5052c61.pdf

15. https://www.researchgate.net/publication/312142584_The_photobiomodulation_effect_of_higher-fluence_808- nm_laser_therapy_with_a_flattop_handpiece_on_the_wound_healing_of_the_earthworm_Dendrobaena_veneta_a_brief_report

16. Wound healing LED shows significant speed of recovery with 633nm.


17. Scarring


18. Dermal Abrasions



19. https://www.ncbi.nlm.nih.gov/pubmed/27345389

20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538543/

21. https://www.ncbi.nlm.nih.gov/pubmed/17463313/

22. https://www.ncbi.nlm.nih.gov/pubmed/17678491/


23. https://www.ncbi.nlm.nih.gov/pubmed/28846932

Transcranial effect of LED

24. https://www.researchgate.net/publication/273781132_Red_and_NIR_light_dosimetry_in_the_human_deep_brain

Brain Injury 

25. https://www.researchgate.net/publication/229161498_Transcranial_low_level_laser_light_therapy_for_traumatic_brain_injury

26. https://www.ncbi.nlm.nih.gov/pubmed/17439348

27. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397203/

28. https://www.ncbi.nlm.nih.gov/pubmed/11059663


29. https://www.ncbi.nlm.nih.gov/pubmed/12811613

30. https://www.ncbi.nlm.nih.gov/pubmed/12811613

Testosterone replacement

31. http://connection.ebscohost.com/c/articles/96971683/effects-low-level-laser-therapy-red%20and%20near-infrared%20light-testis-elevating-serum-testosterone-level-rats

Headache Light therapy modulates serotonin levels and blood flow in women with headache. A preliminary study.

32. https://www.ncbi.nlm.nih.gov/pubmed/26202374

Dermal Abrasions

33. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766381/


34. https://www.ncbi.nlm.nih.gov/pubmed/226734405


35. https://www.ncbi.nlm.nih.gov/pubmed/24801056

Effectiveness of low-level laser therapy on pain intensity, pressure pain threshold, and SF-MPQ indexes of women with myofascial pain. :10.11607/ofph.2032. Epub 2018 Apr 25.

Efficacy of Low-Level Laser Therapy in the Treatment of Temporomandibular Myofascial Pain: A Systematic Review and Meta-Analysis.

36. https://www.ncbi.nlm.nih.gov/pubmed/29697718


37. https://www.ncbi.nlm.nih.gov/pubmed/16468292

38. https://www.ncbi.nlm.nih.gov/pubmed/28232927

Comparison of Red and Infrared Low-level Laser Therapy in the Treatment of Acne Vulgaris.

39. https://www.ncbi.nlm.nih.gov/pubmed/22615511

Sunlight Incidence, Vitamin D Deficiency, and Alzheimer's Disease.

40. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454613/

Depression Long term study

41. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556873/

Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety:

42. https://www.ncbi.nlm.nih.gov/pubmed/19995444

Transcranial Laser Stimulation as Neuroenhancement for Attention Bias Modification in Adults with Elevated Depression Symptoms.

43. https://www.ncbi.nlm.nih.gov/pubmed/27267860

Low-Level Laser Irradiation Improves Depression-Like Behaviors in Mice.

44. https://www.ncbi.nlm.nih.gov/pubmed/27379735


Saltmarche AE, Naeser MA, Ho KF, Hamblin MR, Lim L. Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report. Photomed Laser Surg. 2017;35(8):432-441

45. https://www.ncbi.nlm.nih.gov/pubmed/28186867 dementia, memory, mood

General Brain Health & Cognitive Performance. 

Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans.

46. https://www.ncbi.nlm.nih.gov/pubmed/23200785

Shining light on the head: Photobiomodulation for brain disorders

47. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066074/

Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation

48. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568598/

Review of transcranial photobiomodulation for major depressive disorder: targeting brain metabolism, inflammation, oxidative stress, and neurogenesis

49. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777909/

Emotional responses and memory performance of middle-aged CD1 mice in a 3D maze: Effects of low infrared light

50. https://www.sciencedirect.com/science/article/pii/S1074742707001153

Improving executive function using transcranial infrared laser stimulation.

51. https://www.ncbi.nlm.nih.gov/pubmed/26017772

52. https://www.ncbi.nlm.nih.gov/pubmed/26535475

Cognitive enhancement by transcranial laser stimulation and acute aerobic exercise.

53. https://www.ncbi.nlm.nih.gov/pubmed/27220529

Neurological and psychological applications of transcranial lasers and LEDs.

54. https://www.ncbi.nlm.nih.gov/pubmed/23806754

Alzheimers Disease

Low-Level Laser Therapy Ameliorates Disease Progression in a Mouse Model of Alzheimer’s Disease

55. https://www.researchgate.net/publication/263742704_Low- Level_Laser_Therapy_Ameliorates_Disease_Progression_in_a_Mouse_Model_of_Alzheimer's_Disease 

Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models.

56. https://www.ncbi.nlm.nih.gov/pubmed/24387311

Low-level laser therapy rescues dendrite atrophy via upregulating BDNF expression: implications for Alzheimer's disease.

57. https://www.ncbi.nlm.nih.gov/pubmed/23946409


Is bipolar disorder an inflammatory condition? The relevance of microglial activation.

58. https://www.ncbi.nlm.nih.gov/pubmed/23196997


mice subjected to acute arthritis condition.

59. https://www.ncbi.nlm.nih.gov/pubmed/28772237

Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation.

60. https://www.ncbi.nlm.nih.gov/pubmed/24028507

Bell's Palsy -

61. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322014/


62. The effects of low level laser therapy (LLLT) on the testis in elevating serum testosterone level in rats http://connection.ebscohost.com/c/articles/96971683/effects-low-level-lasertherapy-red%20and%20near-infrared%20light-testis-elevating-serum-testosterone-level-rats

Aging Skin

Regulation of Skin Collagen Metabolism In VitroUsing a Pulsed 660 nm LED Light Source: Clinical Correlation with a Single- Blinded Study

63. https://www.sciencedirect.com/science/article/pii/S0022202X15341749

Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring

64. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126803/


Low Level Laser Therapy: A Panacea for oral maladies

65. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639680/

NUTS AND BOLTS OF LLLT - Survey of Basically Everything treated by LLLT

66. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288797/

MECHANISM OF ACTION OF LLLT - dose, etc. Biphasic Dose Response in Low Level Light

67. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790317/ 

The role of nitric oxide in low level light therapy

68. https://www.researchgate.net/publication/237089612_The_role_of_nitric_oxide_in_low_level_light_therapy How Mitochondria absorb visible light

69. https://www.researchgate.net/publication/237089612_The_role_of_nitric_oxide_in_low_level_light_therapy


A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase.

70. https://www.ncbi.nlm.nih.gov/pubmed/24286286

71. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332991/

Effects of radiofrequency, electroacupuncture, and low-level laser therapy on the wrinkles and moisture content of the forehead, eyes, and cheeks Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring.

72. https://www.ncbi.nlm.nih.gov/pubmed/24049929

73. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126803/


74. Low-Level Laser Therapy for Fat Layer Reduction: A Comprehensive Review 


“Overweight and obesity.” Centers for Disease Control and Prevention (2007). Available:

75. https://www.cdc.gov/onsidty/data/ad/ult.html

Sene-fiorense M, Duarte FO, De aquino junior, et al. The potential of phototherapy to reduce body fat, insulin resistance and “metabolic inflexibility” related to obesity in women undergoing weight loss treatment. Lasers Sung Med. 2015;47(7):634-42

76. https://www.ncbi.nlm.nih.gov/pubmed/26220050

Ger Med Sci. 2006 Jul 11:4; Doc05. Influence of water-filtered infrared-A (wiRA) on reduction of local fat and body weight by physical exercise. Mockel F, Hoffman G, Obermuller R, Drobnik W,Schmitz G.

77. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703221/

Mcrae E, Boris J. Independent evaluation of low-level laser therapy 635nm for non-invasive body contouring of the waist, hips and thighs. Lasers Surg Med. 2013;45(1):1-7.

78. https://www.ncbi.nlm.nih.gov/pubmed/23355338

79. 635nm - 660nm for Fat Loss


80. Low-Level Laser Therapy for Fat Layer Reduction: A Comprehensive Review 


Health After Cancer

81. Warburg O. Uber den Stoffweschsel der Hefe. Pp253-254

82. Bianconi E., Piovesan A, Facchin F, et al. An estimation of the number of cells in the human body. Ann Hun Biol 2013:40(6):463-71

83. https://www.researchgate.net/publication/306325596_Revised_Estimates_for_the_Number_of_Human_and_Bacteria_Cells_in_the_Body

84. Li, Y., Park, JS., Deng, JH. Et al. Cytochrome c oxidase subunit IV is useful for assembly and respiratory function of the enzyme complex. J Bioenerg, Biomember (2006)38;283

85. Brown GC, Borutalite V. Nitric Oxide, cytochrome c, and mitochondria. Biochem Soc. Symp. 1999:66;17-25



Therapeutic photobiomodulation: nitric oxide and a novel function of mitochondrial cytochrome c oxidase.

86. https://www.ncbi.nlm.nih.gov/pubmed/21356170

Inflammation in general:

Mechanisms and applications of the anti-inflammatory effects of photobiomodulation

87. https://www.ncbi.nlm.nih.gov/pubmed/28748217 

Veterinary Medicine and Photobiomodulation

88. http://veterinarymedicine.dvm360.com/photobiomodulation-facts-and-functions-veterinary-rehab 

An investigation into the depth of penetration of low level laser therapy through the equine tendon in vivo

89. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113823/


90. https://www.ncbi.nlm.nih.gov/pubmed/26427443 

Photobiomodulation for the treatment of retinal diseases: a review

91. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768515/

Photobiomodulation reduces drusen volume and improves visual acuity and contrast sensitivity in dry age‐related macular degeneration

92. https://www.ncbi.nlm.nih.gov/pubmed/11845369

93. https://www.ncbi.nlm.nih.gov/pubmed/16120414

Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy.

Effect of equal daily doses achieved by different power densities of low-level laser therapy at 635 nm on open skin wound healing in normal and diabetic rats.

94. https://www.ncbi.nlm.nih.gov/pubmed/24551842/

Viral Warts


Plantar Warts

96. https://www.ncbi.nlm.nih.gov/pubmed/16942430?dopt=Citation


97. https://www.ncbi.nlm.nih.gov/pubmed/16780494?dopt=Citation

98. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751092/


99. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751092/


100. https://www.researchgate.net/publication/320600622_A_clinical_review_of_phototherapy_for_psoriasis

Improved Sleep & PTSD

101. https://www.ncbi.nlm.nih.gov/pubmed/24568233

Thyroid Tissue Generation

102. https://www.ncbi.nlm.nih.gov/pubmed/22718472

103. https://thyroidpharmacist.com/articles/lasers-thyroid-tissue-regeneration/

104. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534372/

105. https://www.ncbi.nlm.nih.gov/pubmed/20662037

Muscle Performance and Recovery Effect of low-level laser therapy on muscle adaptation to knee extensor eccentric training

106. https://www.researchgate.net/publication/269412590_Effect_of_low-level_laser_therapy_on_muscle_adaptation_to_knee_extensor_eccentric_training

107. Low-level laser (light) therapy (LLLT) on muscle tissue: performance, fatigue and repair benefited by the power of light.

108. Cleber Ferraresi et al. 2012


Does Phototherapy Enhance Skeletal Muscle Contractile Function and Postexercise Recovery? A Systematic Review. Paul A Borsa et al. 2013

109. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554033/ Verifies the benefit of LLLT in all phases of muscle recovery: 107

110. https://www.unip.br/presencial/comunicacao/publicacoes/ics/edicoes/2010/03_jul-set/V28_n3_2010_p286-288.pdf

Photobiomodulation therapy for the improvement of muscular performance and reduction of muscular fatigue associated with exercise in healthy people: a systematic review and meta-analysis.

111. https://www.ncbi.nlm.nih.gov/pubmed/29090398

Photobiomodulation Therapy Improves Performance and Accelerates Recovery of High-Level Rugby Players in Field Test: A Randomized, Crossover, Double-Blind, Placebo-Controlled Clinical Study. Pinto HD et al. 2016

112. https://www.ncbi.nlm.nih.gov/pubmed/27050245

Light-emitting diode therapy in exercise-trained mice increases muscle performance, cytochrome c oxidase activity, ATP and cell proliferation. Ferraresi C et al. 2016

113. https://www.ncbi.nlm.nih.gov/pubmed/25378263

Effects of Light-Emitting Diode Therapy on Muscle Hypertrophy, Gene Expression, Performance, Damage, and Delayed- Onset Muscle Soreness: Case-control Study with a Pair of Identical Twins. Ferraresi C et al. 2016

114. https://www.ncbi.nlm.nih.gov/pubmed/27088469

Diabetic Neuropathy

115. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639677/

116. https://www.researchgate.net/publication/7272502_Improved_foot_sensitivity_and_pain_reduction_in_patients_with_peripheral_neuropathy_after_treatment_with_monochromatic_infrared_photo_energy_-


Bell's Palsy

117. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838725/

118. http://www.litecure.com/wp-content/uploads/2016/09/Laser-Bells-Palsy.pdf

119. https://www.researchgate.net/publication/271346875_Helium_neon_and_diode_laser_therapy_is_an_effective_adjunctive_therapy_for_facial_paralysis

The Therapy Mini

The Neuro Wrap for Mental Acuity & Mood

Nushape exists to develop top-tier, industry-leading LED light therapy devices for photobiomodulation. Implementation of specific wavelengths of LED light can effectively enhance bodily processes by improving mitochondrial health, ATP production; ultimately aiding the cellular ability to work faster, stronger.

Jessica Charles

The year was 2015 and I was happily helping clients in my Santa Barbara Spa. So many of my clients would ask me for safer, alternative methods for lipo or plastic surgery to help them kickstart that life-change to a healthier, happier lifestyle. I started looking into how lightwaves work and the intricacies of how light therapy influences fat-loss and other bodily processes. Becoming completely enthralled with this unique approach to wellness and how it could help my clients, my interest grew to obsession and resulted in the phototherapy start-up, Nushape LLC. Originally Nushape was only offered in spas and doctors offices, but with our current collection we're happy to be delivering clinical strength light therapy directly at home. Welcome and thanks for reading!

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