History - Frieman, father of LLLT


History, Mechanism, Dose, Mitochondrial, Anti-inflammatory


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215870/


History, Mechanism, Dose, Mitochondrial, Anti-inflammatory


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215870/


Visible Light therapy vs. Near Infrared Light therapy


https://www.mamanatural.com/near-infrared-sauna/


History, Mechanism, Dose, Mitochondrial, Antinflammatory


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215870/


Sunlight Incidence, Vitamin D Deficiency, and Alzheimer's Disease


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454613/


Artificial Light and Cancer - Mal Illumination


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454613/


Artificial Light and Obesity


https://www.nature.com/articles/ijo2015255

https://academic.oup.com/aje/article/180/3/245/2739112

Light at night clock and metabolism


https://academic.oup.com/edrv/article/35/4/648/2354673


History, Mechanism, Dose, Mitochondrial, Antinflammatory


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215870/


Diabetic Neuropathy


https://www.researchgate.net/publication/7272502_Improved_foot_sensitivity_and_pain_reduction_in_patients_with_peripheral_neuropathy_after_treatment_with_monochromatic_infrared_photo_energy_-_MIRE

Hair Loss


https://www.aad.org/media/stats/conditions/skin-conditions-by-the-numbers

https://www.ncbi.nlm.nih.gov/pubmed/23970445

Wound Healing, dairy cattle, cat tongue


https://www.ncbi.nlm.nih.gov/pubmed/9068161

https://pdfs.semanticscholar.org/7762/57f1debd12c652310bd11d8d53cfc5052c61.pdf

https://www.researchgate.net/publication/312142584_The_photobiomodulation_effect_of_higher-fluence_808- nm_laser_therapy_with_a_flattop_handpiece_on_the_wound_healing_of_the_earthworm_Dendrobaena_veneta_a_brief_report

Wound healing LED shows significant speed of recovery with 633nm


https://www.ncbi.nlm.nih.gov/pubmed/16581685


Scarring


https://www.ncbi.nlm.nih.gov/pubmed/26741110


Dermal Abrasions


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766381/


Stroke


https://www.ncbi.nlm.nih.gov/pubmed/27345389

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538543/

https://www.ncbi.nlm.nih.gov/pubmed/17463313/

https://www.ncbi.nlm.nih.gov/pubmed/17678491/

Osteoporosis

https://www.ncbi.nlm.nih.gov/pubmed/28846932

Transcranial effect of LED

https://www.researchgate.net/publication/273781132_Red_and_NIR_light_dosimetry_in_the_human_deep_brain

Brain Injury


https://www.researchgate.net/publication/229161498_Transcranial_low_level_laser_light_therapy_for_traumatic_brain_injury

https://www.ncbi.nlm.nih.gov/pubmed/17439348

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397203/

https://www.ncbi.nlm.nih.gov/pubmed/11059663

Sleep

https://www.ncbi.nlm.nih.gov/pubmed/12811613


Testosterone replacement


http://connection.ebscohost.com/c/articles/96971683/effects-low-level-laser-therapy-red%20and%20near-infrared%20light-testis-elevating-serum-testosterone-level-rats

Headache Light therapy modulates serotonin levels and blood flow in women with headache. A preliminary study.


https://www.ncbi.nlm.nih.gov/pubmed/26202374


Dermal Abrasions


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766381/


Tendonitis

https://www.ncbi.nlm.nih.gov/pubmed/226734405


Fibromayalgia

https://www.ncbi.nlm.nih.gov/pubmed/24801056

Effectiveness of low-level laser therapy on pain intensity, pressure pain threshold, and SF-MPQ indexes of women with myofascial pain. :10.11607/ofph.2032. Epub 2018 Apr 25.

Efficacy of Low-Level Laser Therapy in the Treatment of Temporomandibular Myofascial Pain: A Systematic Review and Meta-Analysis.

https://www.ncbi.nlm.nih.gov/pubmed/29697718


Acne

https://www.ncbi.nlm.nih.gov/pubmed/16468292

38. https://www.ncbi.nlm.nih.gov/pubmed/28232927

Comparison of Red and Infrared Low-level Laser Therapy in the Treatment of Acne Vulgaris.

https://www.ncbi.nlm.nih.gov/pubmed/22615511

Sunlight Incidence, Vitamin D Deficiency, and Alzheimer's Disease.


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454613/


Depression Long term study


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556873/


Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety


https://www.ncbi.nlm.nih.gov/pubmed/19995444



Transcranial Laser Stimulation as Neuroenhancement for Attention Bias Modification in Adults with Elevated Depression Symptoms.


https://www.ncbi.nlm.nih.gov/pubmed/27267860


Low-Level Laser Irradiation Improves Depression-Like Behaviors in Mice.


https://www.ncbi.nlm.nih.gov/pubmed/27379735


Dementia

Saltmarche AE, Naeser MA, Ho KF, Hamblin MR, Lim L. Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation: Case Series Report. Photomed Laser Surg. 2017;35(8):432-441

https://www.ncbi.nlm.nih.gov/pubmed/28186867dementia, memory, mood

General Brain Health & Cognitive Performance.

Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans.


https://www.ncbi.nlm.nih.gov/pubmed/23200785



Shining light on the head: Photobiomodulation for brain disorders


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066074/


Significant Improvement in Cognition in Mild to Moderately Severe Dementia Cases Treated with Transcranial Plus Intranasal Photobiomodulation

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568598/


Review of transcranial photobiomodulation for major depressive disorder: targeting brain metabolism, inflammation, oxidative stress, and neurogenesis


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4777909/


Emotional responses and memory performance of middle-aged CD1 mice in a 3D maze: Effects of low infrared light


 https://www.sciencedirect.com/science/article/pii/S1074742707001153


Improving executive function using transcranial infrared laser stimulation.


https://www.ncbi.nlm.nih.gov/pubmed/26017772

https://www.ncbi.nlm.nih.gov/pubmed/26535475

Cognitive enhancement by transcranial laser stimulation and acute aerobic exercise.


https://www.ncbi.nlm.nih.gov/pubmed/27220529

Neurological and psychological applications of transcranial lasers and LEDs.

https://www.ncbi.nlm.nih.gov/pubmed/23806754

Alzheimers Disease


Low-Level Laser Therapy Ameliorates Disease Progression in a Mouse Model of Alzheimer’s Disease

https://www.researchgate.net/publication/263742704_Low- Level_Laser_Therapy_Ameliorates_Disease_Progression_in_a_Mouse_Model_of_Alzheimer's_Disease

Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex - evidence from two transgenic mouse models.

https://www.ncbi.nlm.nih.gov/pubmed/24387311


Low-level laser therapy rescues dendrite atrophy via upregulating BDNF expression: implications for Alzheimer's disease.


https://www.ncbi.nlm.nih.gov/pubmed/23946409


Bipolar

Is bipolar disorder an inflammatory condition? The relevance of microglial activation.

https://www.ncbi.nlm.nih.gov/pubmed/23196997

Arthritis

mice subjected to acute arthritis condition.

https://www.ncbi.nlm.nih.gov/pubmed/28772237

Effect of low-level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation.

https://www.ncbi.nlm.nih.gov/pubmed/24028507

Bell's Palsy

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322014/


Testosterone

The effects of low level laser therapy (LLLT) on the testis in elevating serum testosterone level in rats

http://connection.ebscohost.com/c/articles/96971683/effects-low-level-lasertherapy-red%20and%20near-infrared%20light-testis-elevating-serum-testosterone-level-rats

Aging Skin

Regulation of Skin Collagen Metabolism In VitroUsing a Pulsed 660 nm LED Light Source: Clinical Correlation with a Single- Blinded Study

https://www.sciencedirect.com/science/article/pii/S0022202X15341749

Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126803/

ORAL HEALTH

Low Level Laser Therapy: A Panacea for oral maladies

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639680/

NUTS AND BOLTS OF LLLT - Survey of Basically Everything treated by LLLT

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288797/

MECHANISM OF ACTION OF LLLT - dose, etc. Biphasic Dose Response in Low Level Light

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790317/

The role of nitric oxide in low level light therapy

https://www.researchgate.net/publication/237089612_The_role_of_nitric_oxide_in_low_level_light_therapyHow Mitochondria absorb visible light

https://www.researchgate.net/publication/237089612_The_role_of_nitric_oxide_in_low_level_light_therapy

REVERSAL OF AGING USING RED LIGHT AND NEAR-INFRARED LIGHT THERAPY

A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase.

https://www.ncbi.nlm.nih.gov/pubmed/24286286

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5332991/


ELIMINATION OF FAT

Effects of radiofrequency, electroacupuncture, and low-level laser therapy on the wrinkles and moisture content of the forehead, eyes, and cheeks Low-level laser (light) therapy (LLLT) in skin: stimulating, healing, restoring.

https://www.ncbi.nlm.nih.gov/pubmed/24049929

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126803/

“Overweight and obesity.” Centers for Disease Control and Prevention (2007). Available


Low-Level Laser Therapy for Fat Layer Reduction: A Comprehensive Review

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769994/

Sene-fiorense M, Duarte FO, De aquino junior, et al. The potential of phototherapy to reduce body fat, insulin resistance and “metabolic inflexibility” related to obesity in women undergoing weight loss treatment. Lasers Sung Med. 2015;47(7):634-42


https://www.cdc.gov/onsidty/data/ad/ult.html


Ger Med Sci. 2006 Jul 11:4; Doc05. Influence of water-filtered infrared-A (wiRA) on reduction of local fat and body weight by physical exercise. Mockel F, Hoffman G, Obermuller R, Drobnik W,Schmitz G.


https://www.ncbi.nlm.nih.gov/pubmed/26220050


Mcrae E, Boris J. Independent evaluation of low-level laser therapy 635nm for non-invasive body contouring of the waist, hips and thighs. Lasers Surg Med. 2013;45(1):1-7.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703221/

635nm - 660nm for Fat Loss

https://www.ncbi.nlm.nih.gov/pubmed/23355338

Low-Level Laser Therapy for Fat Layer Reduction: A Comprehensive Review

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225499/

Li, Y., Park, JS., Deng, JH. Et al. Cytochrome c oxidase subunit IV is useful for assembly and respiratory function of the enzyme complex. J Bioenerg, Biomember (2006)38;283


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769994/

Brown GC, Borutalite V. Nitric Oxide, cytochrome c, and mitochondria. Biochem Soc. Symp. 1999:66;17-25


https://www.ncbi.nlm.nih.gov/pubmed/10989653


LIGHT MEDICINE AND ANIMALS


Therapeutic photobiomodulation: nitric oxide and a novel function of mitochondrial cytochrome c oxidase.

https://www.ncbi.nlm.nih.gov/pubmed/21356170

Inflammation in general

Mechanisms and applications of the anti-inflammatory effects of photobiomodulation

https://www.ncbi.nlm.nih.gov/pubmed/28748217

Veterinary Medicine and Photobiomodulation

http://veterinarymedicine.dvm360.com/photobiomodulation-facts-and-functions-veterinary-rehab

An investigation into the depth of penetration of low level laser therapy through the equine tendon in vivo

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113823/

EYE HEALTH AND WOUND HEALING

https://www.ncbi.nlm.nih.gov/pubmed/26427443

Photobiomodulation for the treatment of retinal diseases: a review

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768515/

Photobiomodulation reduces drusen volume and improves visual acuity and contrast sensitivity in dry age‐related macular degeneration

https://www.ncbi.nlm.nih.gov/pubmed/11845369

https://www.ncbi.nlm.nih.gov/pubmed/16120414

Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy.

Effect of equal daily doses achieved by different power densities of low-level laser therapy at 635 nm on open skin wound healing in normal and diabetic rats.

https://www.ncbi.nlm.nih.gov/pubmed/24551842/

Viral Warts

https://www.researchgate.net/publication/269749233_PULSED_DYE_LASER_TREATMENT_FOR_RECALCITRANT_VIRAL_WARTS_AUTO-SIMULTANEOUS_LASER_TREATMENT

Plantar Warts

https://www.ncbi.nlm.nih.gov/pubmed/16942430?dopt=Citation



Dermatitis

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751092/

Psoriasis


https://www.researchgate.net/publication/320600622_A_clinical_review_of_phototherapy_for_psoriasis

Improved Sleep & PTSD


https://www.ncbi.nlm.nih.gov/pubmed/24568233


Thyroid Tissue Generation


https://www.ncbi.nlm.nih.gov/pubmed/22718472

https://thyroidpharmacist.com/articles/lasers-thyroid-tissue-regeneration/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534372/

https://www.ncbi.nlm.nih.gov/pubmed/20662037

Muscle Performance and Recovery Effect of low-level laser therapy on muscle adaptation to knee extensor eccentric training


https://www.researchgate.net/publication/269412590_Effect_of_low-level_laser_therapy_on_muscle_adaptation_to_knee_extensor_eccentric_training

Low-level laser (light) therapy (LLLT) on muscle tissue: performance, fatigue and repair benefited by the power of light.

Cleber Ferraresi et al. 2012

https://www.ncbi.nlm.nih.gov/pubmed/23626925

Does Phototherapy Enhance Skeletal Muscle Contractile Function and Postexercise Recovery? A Systematic Review. Paul A Borsa et al. 2013


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554033/Verifies the benefit of LLLT in all phases of muscle recovery: 107

https://www.unip.br/presencial/comunicacao/publicacoes/ics/edicoes/2010/03_jul-set/V28_n3_2010_p286-288.pdf

Photobiomodulation therapy for the improvement of muscular performance and reduction of muscular fatigue associated with exercise in healthy people: a systematic review and meta-analysis.

https://www.ncbi.nlm.nih.gov/pubmed/29090398

Photobiomodulation Therapy Improves Performance and Accelerates Recovery of High-Level Rugby Players in Field Test: A Randomized, Crossover, Double-Blind, Placebo-Controlled Clinical Study. Pinto HD et al. 2016

https://www.ncbi.nlm.nih.gov/pubmed/27050245

Light-emitting diode therapy in exercise-trained mice increases muscle performance, cytochrome c oxidase activity, ATP and cell proliferation. Ferraresi C et al. 2016

https://www.ncbi.nlm.nih.gov/pubmed/25378263

Effects of Light-Emitting Diode Therapy on Muscle Hypertrophy, Gene Expression, Performance, Damage, and Delayed- Onset Muscle Soreness: Case-control Study with a Pair of Identical Twins. Ferraresi C et al. 2016

https://www.ncbi.nlm.nih.gov/pubmed/27088469

Diabetic Neuropathy


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639677/

https://www.researchgate.net/publication/7272502_Improved_foot_sensitivity_and_pain_reduction_in_patients_with_peripheral_neuropathy_after_treatment_with_monochromatic_infrared_photo_energy_-

_MIRE

Bells Palsy


https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838725/

http://www.litecure.com/wp-content/uploads/2016/09/Laser-Bells-Palsy.pdf

https://www.researchgate.net/publication/271346875_Helium_neon_and_diode_laser_therapy_is_an_effective_adjunctive_therapy_for_facial_paralysis